Google DeepMind and Isomorphic Labs present in 2024 AlphaFold 3, an AI model that predicts the structure and interactions of virtually all the molecules of life — proteins, DNA, RNA, ligands, and ions — with unprecedented accuracy, broadening the scope of earlier versions (AlphaFold, 2020; AlphaFold 2, 2020) focused on predicting individual protein structure. Unlike its predecessors, AlphaFold 3 incorporates a diffusion module that also allows modeling pathological protein misfolding, the same underlying problem that decades earlier motivated Stanley Prusiner's research on prions. The model was published in a paper in Nature in June 2024, and its code and weights were released for academic use in November of that year.