Wikinventia — Atlas of discoveries and inventions · Global Age

Experimental demonstration of messenger RNA — Brenner, Jacob, and Meselson

1961 AD · Transmission: Global
BiologyDiscoveryBritishFrenchNorth American

Sydney Brenner (Cavendish Laboratory, Cambridge), François Jacob (Pasteur Institute, Paris), and Matthew Meselson (Caltech) experimentally demonstrate in 1961 the existence of messenger RNA (mRNA): a short-lived RNA molecule that carries genetic information from DNA to the ribosomes, where proteins are synthesized. The idea had been conceived by Brenner and Crick in April 1960 following a conversation with Jacob about the PaJaMo experiment (Pardee-Jacob-Monod). The experimental work was carried out in summer 1960 in Meselson's laboratory at Caltech, using bacteriophage T2 on E. coli to distinguish old from new ribosomes via density-gradient centrifugation. Jacob and Monod coined the term 'messenger RNA' while analyzing the results. Published in Nature on May 13, 1961, in a joint paper with Watson's group after a request from Watson to delay publication until his team completed their own parallel work.

InstitutionCavendish Laboratory (Cambridge) / Institut Pasteur (Paris) / California Institute of Technology
Historical regionUnited Kingdom / France / United States
Primary sourceBrenner, S., Jacob, F., Meselson, M. — "An Unstable Intermediate Carrying Information from Genes to Ribosomes for Protein Synthesis". Nature 190 (1961), 576–580.
Original languageEnglish
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