Wikinventia — Atlas of discoveries and inventions · Digital Age

CRISPR-Cas9 as a gene-editing tool — Doudna and Charpentier

2012 AD · Transmission: Global
BiologyMethodNorth American

Doudna and Charpentier adapt the bacterial CRISPR-Cas9 immune system as a precise, low-cost genome-editing tool. It allows editing any gene in any organism. In 2024 the first CRISPR therapy in humans is approved (Casgevy, sickle cell disease).

InstitutionUC Berkeley / Institut Pasteur / Umeå University
Historical regionUnited States / France
Primary sourceJinek, M. et al. — "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" (Science, 2012)
Secondary sourceNobel Prize — Chemistry 2020
Original languageEnglish
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